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Showing posts with the label DNA repair

Can cancer-related RNA modification machinery abnormalities are both hereditary and epigenetic?

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  In mammals, tissue-specific gene expression patterns must be maintained and properly developed through the use of epigenetic processes. Cancer was once thought to be a solely hereditary disease, however dysregulated genetic and epigenetic processes are now recognized to play a role in the cancer phenotype. More recently, it has been discovered that chemical alterations of RNA molecules, or the so-called epitranscriptome, control a number of RNA function and homeostasis-related processes. Depositing, deleting, and reading chemical alterations from RNA are carried out by certain enzymes called RNA-modifying proteins (RMPs). The crucial function of RNA changes in controlling a variety of biological pathways has recently been made clear by extensive research in the epitranscriptomic field and significant technical advancements. The fact that RNA modification machinery is frequently altered in human malignancies, as shown by mounting data, emphasises the immense potential of RMPs...

Does sleeping affect your genes?

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Hope you may plan to a movie or binge-watching on a weekend night   You might think that nothing is going wrong and you were just chilling out, Exactly it was not the thing that was happening …… Your internal cells are yelling at your brain cells, "Hey, what's wrong with you? We need sleep and have more system repairs to make." Your cells from inside are screaming on your brain cells like; “Hey, what’s wrong with you, we need sleep and have more repair work to do in our system.” Again lost in thoughts? Yes, our body sweeps entire toxins by the fluid, produced while sleeping and all the DNA damages are repaired well at night. Lack of sleep is linked to increased DNA breaks and decreased DNA repair gene expression, according to a study. The higher risk of malignancies and neurological illnesses in persons who lack sleep may be explained by DNA damage.