Can cancer-related RNA modification machinery abnormalities are both hereditary and epigenetic?

 

In mammals, tissue-specific gene expression patterns must be maintained and properly developed through the use of epigenetic processes.

Cancer was once thought to be a solely hereditary disease, however dysregulated genetic and epigenetic processes are now recognized to play a role in the cancer phenotype. More recently, it has been discovered that chemical alterations of RNA molecules, or the so-called epitranscriptome, control a number of RNA function and homeostasis-related processes. Depositing, deleting, and reading chemical alterations from RNA are carried out by certain enzymes called RNA-modifying proteins (RMPs). The crucial function of RNA changes in controlling a variety of biological pathways has recently been made clear by extensive research in the epitranscriptomic field and significant technical advancements. The fact that RNA modification machinery is frequently altered in human malignancies, as shown by mounting data, emphasises the immense potential of RMPs as pharmaceutical targets or diagnostic indicators.


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